Insilico Medicine Successfully Discovered Potent, Selective, and Orally Bioavailable Small Molecule Inhibitor of CDK8 Using Generative AI

Abu Dhabi, April 24, 2023 (GLOBE NEWSWIRE) — Insilico Medicine ("Insilico"), a clinical–stage generative artificial intelligence (AI)–driven drug discovery company which operates the largest AI–powered biotech R&D center in the Middle East, announced that it has successfully discovered a potent, selective, and orally bioavailable small molecule inhibitor of CDK8 for the treatment of cancer using a structure–based generative chemistry approach enabled by the Chemistry42 generative reinforcement learning platform. The research was published in the American Chemical Society's Journal of Medicinal Chemistry, a leading journal in medicinal chemistry.

As members of the CDK family, CDK8 and its paralog protein CDK19 play critical roles in regulating transcription of many different signaling pathways involved in oncogenic control. Deregulation of CDK8/19 has been implicated as a driving force in many human cancers, particularly in acute myeloid leukemia (AML) and advanced solid tumors. Moreover, CDK8/19 is also involved in immune modulation. Targeting CDK8/19 could enhance NK cell cytotoxicity and stimulate NK cell–mediated tumor surveillance. Therefore, targeting CDK8/19 is regarded as a promising strategy with a two–in–one mechanism of action that not only inhibits tumor cell growth, but also increases immune cell activity.

The research published by Insilico was supported by its generative chemistry engine, Chemistry42, which is built on years of modeling and pre–training of large biological, chemical and textual datasets. Chemistry42 includes 42 generative engines and more than 500 predictive engines for scoring which allows researchers to generate molecules with desired properties from scratch using deep learning technologies through structure–based drug design (SBDD) and ligand–based drug design (LBDD).

In this study, scientists described the process of using the SBDD module of Chemistry42 to generate a key anchor linker and identify the hit compound targeting CDK8. Over several optimization cycles, R&D scientists further improved in vitro metabolic stability, kinase selectivity, and in vivo pharmacokinetic profile cross–species, leading to the discovery of one potent, selective, and orally bioavailable inhibitor of CDK8, which was evaluated in in vivo efficacy studies and demonstrated robust tumor growth inhibition in multiple in vivo efficacy models.

In addition to the published molecule, Insilico scientists are progressing with another AI–generated CDK8 inhibitor with a novel structure. Insilico is open to potential partnerships with pharmaceutical companies to co–develop the drug candidate.

"At Insilico, we encourage scientists to share their innovative insights in AI–driven drug discovery with the industry by publishing peer–reviewed papers," said Feng Ren, PhD, Co–CEO and Chief Scientific Officer of Insilico Medicine. "In this case, we have not only discovered a novel compound for a promising target, but also provided innovative practices in early drug discovery supported by generative AI."

Insilico has pioneered applying multiple generative approaches for drug design in both generative chemistry and generative biology and published the first paper in generative chemistry. The company then submitted the relevant patents on applying these generative approaches for chemistry and biology, and integrated these approaches into the commercially available Pharma.AI platform, which includes PandaOmics a system utilizing multiple predictive and generative biology models; a generative chemistry engine, Chemistry42; and a clinical trial outcomes prediction engine InClinico, which utilizes a combination of omics–based predictors and text–based transformers. Powered by generative AI, Insilico is delivering breakthroughs for healthcare in multiple disease areas. The lead program targeting fibrosis–driven diseases has completed Phase 0 and Phase I clinical trials and received positive Phase I topline data and Orphan Drug Designation.

"We described the concept of using generative AI for the design of novel molecules in a peer–reviewed journal in 2016 for the first time. Later, we developed multiple approaches and new features for our GAN–based AI platform for drug design. We also started patenting our findings so that ,in some areas, patents preceded publications. Some of my favorite patents combine generative chemistry and generative biology," said Alex Zhavoronkov, PhD, Founder and CEO of Insilico Medicine. "I am excited to see that with the support of generative AI, we have achieved several industry milestones and advanced the drug candidates discovered by generative AI to the clinical stage. In 2022 alone, we nominated 9 preclinical candidates utilizing generative AI. We are committed to refining our approach and tools to reshape the future of healthcare by generative innovation."

About Insilico Medicine

Insilico Medicine, a clinical–stage generative artificial intelligence (AI)–driven drug discovery company, is connecting biology, chemistry, and clinical trials analysis using next–generation AI systems. The company has developed AI platforms that utilize deep generative models, reinforcement learning, transformers, and other modern machine learning techniques for novel target discovery and the generation of novel molecular structures with desired properties. Insilico Medicine is developing breakthrough solutions to discover and develop innovative drugs for cancer, fibrosis, immunity, central nervous system diseases, infectious diseases, autoimmune diseases, and aging–related diseases. In early 2023, the Company opened the Insilico Medicine Generative Artificial Intelligence and Quantum Computing Research and Development Centre in Abu Dhabi, the region's largest AI–powered biotechnology research center. The R&D hub brings together global talent in artificial intelligence and software development to expand the capabilities of Insilico's end–to–end AI–driven drug discovery platform, Pharma.AI, explore aging research and sustainable chemistry, and support the digital transformation of healthcare in the region. www.insilico.com

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GLOBENEWSWIRE (Distribution ID 8824301)

UBTECH Smart Elderly Care Solution honored as the winner of the 2023 Edison Awards™

FORT MYERS, FLORIDA, USA, April 24, 2023 (GLOBE NEWSWIRE) — FORT MYERS, FLORIDA, April 20, 2023— UBTECH, a leading global AI and robotics company, was honored the Bronze award of the 2023 Edison Awards' MedTech category for the distinguished innovation of its Smart Elderly Care Solution.

Known as the “Oscars of tech,” the Edison Awards is one of the oldest and most prestigious technology awards. It honors the most impactful brands and business leaders worldwide, with past winners including Steve Jobs, Elon Musk, General Motors, and Genentech, recognizing their excellence in service development, marketing, design, and innovation.

All nominations were reviewed by the Edison Awards Steering Committee with the final ballot determined by an independent judging panel. The panel is comprised of more than 3,000 senior business executives and academics from the fields of product development, design, engineering, science, marketing and education, as well as past winners.

UBTECH's Smart Elderly Care Solution offers an enriched portfolio of intelligent robots to enhance the quality of life for seniors. In addition to using cutting–edge robotics technologies, the solution also leverages advanced artificial intelligence. And through UBTECH's Smart Healthcare Cloud Platform, the Smart Elderly Care Solution creates a network that enables seamless integration of a variety of devices. This interconnect between hardware, network and people supports the seven key scenarios of smart elderly care: operational management, safety and security, health management, daily care, rehabilitation, mental and physical activities, and nutrition and diet.

"This is the industry's comprehensive solution that combines advanced robotics and AI technology to assist seniors and their caregivers in nursing homes. Rather than providing services using isolated, individual products, we focus on addressing system–level challenges. By extensively applying AI technology, we vastly improved product performance to bring a richer, more optimized experience to the elderly and caregivers," Henry Tan, Co–Chief Technology Officer of UBTECH and General Manager of UBTECH Healthcare, says, "It is an honor to have our Smart Elderly Care Solution be recognized by the Edison Awards."

According to the U.S. Census Bureau, starting in 2030, all baby boomers will be 65 and older. And by 2034, older adults will outnumber children for the first time in U.S. history. This forecast generates demand for efficient, comprehensive assistive care solutions.

Designed for accessibility, UBTECH's Smart Elderly Care Solution portfolio accepts a multitude of inputs. Its smart sensors, working in parallel with its data platform, transform care from passive to proactive in assisting with daily tasks. And with rich interactive features, the solution can support seniors' physical and mental well–being.

Moving into the smart care era, UBTECH provides people with an intelligent, independent, and convenient solution to raise the standard for the elderly care industry. Within the past year, UBTECH has released five service robots: Wassi, an intelligent walking assistance robot; VerCari, a containerized delivery robot; PathFynder, a smart wheelchair; AuCari, an open delivery robot; and Welli, a companion robot.

Due to its utility and innovation, UBTECH's Smart Elderly Care Solution is garnering international interest. The PathFynder smart wheelchair is now exploring market in North America. In addition, UBTECH has worked with companies and partners to deliver and implement the solution in different facilities and scenarios. These successes are encouraging UBTECH to continue its mission to refine its technologies, pushing the industry forward to promote a higher quality of care.

As UBTECH expands its business globally, it expects to generate higher value and provide higher–quality services for seniors worldwide. By continuing to develop robotics and AI, the company aims to address the long–term challenge for society and create a new industry to boost the global economy.

About UBTECH

UBTECH, established in March 2012, is a leading AI and robotics company specializing in service robotics research, manufacturing, and marketing. Throughout the ongoing journey, from establishing an R&D center in North America focusing on the healthcare sector in 2019 focusing on applying solutions in various elderly–care scenarios, to releasing its global strategy for smart elderly–care in 2022, UBTECH has been a pioneer and leader in smart service robotic solutions. UBTECH is committed to the vision of transforming the healthcare industry and the sustainable development of the elderly–care economy with innovative technologies, together with industry partners.

Press contact

Jade Su

Senior PR Manager

Jade.su@ubtrobot.com

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Duck Creek Technologies Unveils a “Who’s Who” Participating in the Insurance Industry’s Leading Conference for Tech Decision Makers, Formation ’23

Boston, April 24, 2023 (GLOBE NEWSWIRE) — Duck Creek Technologies, the intelligent solutions provider defining the future of property and casualty (P&C) and general insurance, announces major sponsors, partners, and presenters joining the leading insurance technology decision makers for its upcoming marquee customer conference, Formation '23. The event is being held May 8 through May 10, 2023, at Signia by Hilton Orlando Bonnet Creek in Orlando, Florida.

With a focus on cultivating a world–class event experience filled with rich content, industry networking opportunities and unforgettable activities, Formation "23 is all about "BUILDING TOGETHER." Duck Creek will welcome the leading insurtech minds and industry professionals of all levels from across the globe in a high–energy environment with ample educational and networking opportunities focused on the latest trends and innovations empowering the insurance industry. Duck Creek is delighted to be joined on stage and in sessions by customers who will share their personal stories and first–hand experiences implementing Duck Creek and partner ecosystem innovations. Notable carriers presenting include Australia–based general insurers Argyle and Hollard, as well as Berkshire Hathaway Specialty Insurance, EMC Insurance Companies, GAINSCO Auto Insurance (GAINSCO), Great American Insurance Group, Indigo Insurance Ltd., and Munich Reinsurance America, Inc.

"This year we have a record number of sponsorship commitments from more than 60 members of our partner ecosystem, including diamond sponsors Glia and LTIMindtree; platinum sponsors Coforge and EY; and gold sponsors Accenture, Aggne Global, Capgemini, Cognizant and Quadient," said Rohit Bedi, Chief Revenue Officer, Duck Creek Technologies. "This is a testimony to the robust partner ecosystem Duck Creek has built to benefit our customers worldwide. We maintain strong relationships with industry leaders to provide complementary, distinct solutions and services to get our joint customers to market quickly."

Notably, several influential industry analysts from Aite–Novarica Group (Aite–Novarica), Celent, Everest Group, Forrester, International Data Corporation (IDC) and ReSource Pro Consulting, will participate in various sessions as guest speakers. In particular, Aite–Novarica, Celent, and Forrester will come together to speak in a panel, "Building the future together," to share how insurers must utilize technology to win in today's market.

Attendees will get first look at Duck Creek's latest product vision, strategy, and roadmap. "Duck Creek is committed to providing great products that enable insurers and their customers to thrive," said Chief Product & Technology Officer Jess Keeney. "We believe great products are personal "" delivered and supported through the research and development of humanized experiences. Insurance is more complex with more regulations than ever, and we provide our customers with better data and more technology to manage increased distribution channels and shifting demographics."

The agenda and speaker line–up are now available on the conference website. For more information on Formation "23 or to register now for the year's must–attend event, please visit https://www.duckcreek.com/formation/.

About Duck Creek Technologies

Duck Creek Technologies is the intelligent solutions provider defining the future of the property and casualty (P&C) and general insurance industry. We are the platform upon which modern insurance systems are built, enabling the industry to capitalize on the power of the cloud to run agile, intelligent, and evergreen operations. Authenticity, purpose, and transparency are core to Duck Creek, and we believe insurance should be there for individuals and businesses when, where, and how they need it most. Our market–leading solutions are available on a standalone basis or as a full suite, and all are available via Duck Creek OnDemand. Visit www.duckcreek.com to learn more. Follow Duck Creek on our social channels for the latest information "" LinkedIn and Twitter.


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Holistic Education Support in Colombia Extended to Counter Snowballing Learning Crisis

ECW High-Level Mission to Colombia ECW Executive Director Yasmine Sherif meets a young female student at the ECW-supported learning facility ‘Eustorgio Colmenares Baptista’, in Cúcuta, Colombia. Disability and inclusion are at the forefront of ECW-supported learning activities. Credit: ECW

ECW High-Level Mission to Colombia
ECW Executive Director Yasmine Sherif meets a young female student at the ECW-supported learning facility ‘Eustorgio Colmenares Baptista’, in Cúcuta, Colombia. Disability and inclusion are at the forefront of ECW-supported learning activities.
Credit: ECW

By Joyce Chimbi
NEW YORK & NAIROBI, Apr 24 2023 – The largest external displacement crisis in Latin America’s recent history is unfolding as countries open their borders to an influx of refugees from Venezuela following unprecedented political turmoil, socio-economic instability, and a humanitarian crisis.

“Venezuela’s ongoing regional crisis is such that more than 6.1 million refugees and migrants have fled the country, triggering the second largest refugee crisis today. Colombia alone is host to 2.5 million Venezuelan refugees and migrants in need of international protection,” Yasmine Sherif, Executive Director of Education Cannot Wait (ECW), tells IPS.

Sherif applauds Colombia for opening its borders despite ongoing challenges within its borders. For, 2.5 million refugees and migrants from Venezuela are in addition to Colombia’s own 5.6 million internally displaced persons (IDPs).

“The Government of Colombia has taken remarkable measures in providing refugees and migrants from Venezuela with access to life-saving essential services like education. By supporting these efforts across the humanitarian-development-peace nexus, we are creating the foundation to build a more peaceful and more prosperous future not only for the people of Colombia but also for the refugees and migrants from Venezuela above all,” she emphasizes.

An influx of refugees and IDPs has heightened the risk of children and adolescents falling out of the education system. As life as they knew it crumbles and uncertainty looms, access to safe, quality, and inclusive education is their only hope.

Girls, children with disability, and those from indigenous and Afro-Colombian peoples are highly vulnerable as they are often left behind, forgotten as a life of missed learning and earning opportunities beckons.

ECW High-Level Mission Delegation, led by Executive Director Yasmine Sherif, and in country partners, Fundación Plan, Norwegian Refugee Council, Save the Children, UNICEF, World Vision at the ECW-supported learning facility ‘Eustorgio Colmenares Baptista’ in Cúcuta, Colombia. Credit: ECW

ECW High-Level Mission Delegation, led by Executive Director Yasmine Sherif, and in-country partners, Fundación Plan, Norwegian Refugee Council, Save the Children, UNICEF, World Vision at the ECW-supported learning facility ‘Eustorgio Colmenares Baptista’ in Cúcuta, Colombia.
Credit: ECW

To avert an education disaster, as many children risk falling off the already fragile education system, ECW intends to continue expanding its investments in Colombia. To deliver the promise of holistic education and give vulnerable children a fighting chance.

ECW has invested close to USD 16.4 million in Colombia since 2019. The fund intends to extend its support with an additional USD 12 million for the next three-year phase of its Multi-Year Resilience Programme, which, once approved, will bring the overall investment in Colombia to over USD 28 million.

The new Multi-Year Resilience Programme will be developed during 2023 – in close consultation with partners and under the leadership of the Government of Colombia – and submitted to ECW’s Executive Committee for final approval in due course.

Sherif, who announced the renewed support during her recent one-week visit to Colombia, stresses that ECW works closely with the Ministry of Education and other line ministries in Colombia to support the government’s efforts to respond to the interconnected crises of conflict, forced displacement, and climate change and still provide quality education.

This collaboration is critical. Despite the government’s commendable efforts to extend temporary protection status to Venezuelans in Colombia, children continue to miss out on their human right to quality education.

In 2021 alone, the dropout rate for Colombian children was already 3.62 percent (3.2 percent for girls and 4.2 percent for boys). The figure nearly doubles for Venezuelans to 6.4 percent, and reaches 17 percent for internally displaced children.

“But even when children are able to attend school, the majority are falling behind. Recent analysis shows that close to 70 percent of ten-year-olds cannot read or understand a simple text, up from 50 percent before the COVID-19 pandemic shut down schools across Colombia,” Sherif observes.

Against this backdrop, she speaks of the urgent need to provide the girls and boys impacted by the interconnected crises of conflict, displacement, climate change, poverty, and instability with the safety, hope, and opportunity of quality education.

ECW’s extended programme will advance Colombia’s support for children and adolescents from Venezuela, internally displaced children, and host-communities, as well as indigenous and Afro-Colombian communities impacted by these ongoing crises.

“ECW’s investment closely aligns with the Government of Colombia’s strategy on inclusion and will strengthen the education system at the national level and in regions most affected by forced displacement. The programme will also have a strong focus on girls’ education so that no one is left behind,” she says.

A young girl does arts and crafts at the ECW-supported Yukpa indigenous school of the Manüracha community in Cúcuta, Colombia. Credit: ECW

A young girl does arts and crafts at the ECW-supported Yukpa indigenous school of the Manüracha community in Cúcuta, Colombia. Credit: ECW

As of November 2022, over half a million Venezuelan children and adolescents have been enrolled in Colombia’s formal education system. ECW investments have reached 107,000 children in the country to date.

“Financing is critical to ensure that no child is left behind. But funds are currently not enough to match the challenges on the ground and the growing needs. An estimated USD 46.4 million is required to fully fund the current multi-year resilience response in Colombia,” Sherif explains.

 ECW’s Multi-year Resilience Programme in Colombia is delivered by UNICEF and a Save the Children-led NGO consortium, including the Norwegian Refugee Council (NRC), World Vision, and Plan International.

ECW investments in Colombia provide access to safe and protective formal and non-formal learning environments, mental health and psychosocial support services, and specialized services to support the transition into the national education system for children at risk of being left behind. A variety of actions to strengthen local and national education authorities’ capacities to support education from early childhood education through secondary school.

IPS UN Bureau Report

 


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The Last Mile to Malaria Elimination: Confronting Gender Inequalities & Power Dynamics

Young girls chat while sitting under a mosquito net in Bienythiang, South Sudan. Credit: UNICEF/Mark Naftalin

 
World Malaria Day, April 25, is an occasion to highlight the need for continued investment and sustained political commitment for malaria prevention and control. It was instituted by WHO Member States during the World Health Assembly of 2007.

By Arthur Ng’etich Kipkemoi Saitabau
KUALA LUMPUR, Malaysia, Apr 24 2023 – For centuries, malaria has remained one of the deadliest diseases, inflicting great suffering on families and perpetuating the cycle of poverty in many communities and nations. The African region currently accounts for 95% of malaria cases and 96% of malaria deaths globally, with women and girls disproportionately affected by the disease.

Women are at higher risk of malaria due to biological, social, economic, and gender factors. They have limited access to healthcare, less decision-making power and control over household resources, which increases their susceptibility.

Gender-based economic disparities further worsen the situation by limiting women’s access to malaria prevention and treatment.

While significant progress has been made in the past decades in combatting malaria through the development of life-saving treatment regimens and the implementation of cutting-edge technologies to accelerate the discovery and development of new malaria vaccines, deaths due to malaria remain high.

In 2021 alone, an estimated 619,000 deaths were caused by malaria, highlighting the need for continued efforts to combat this disease.

In addition, COVID-related disruptions in the delivery of malaria curative and preventive services during the two peak years of the pandemic (2020-2021), led to approximately 13 million more cases of malaria and an additional 63,000 deaths caused by the disease compared to the pre-COVID-19 year of 2019.

To date, malaria cases and deaths have primarily been reduced through disease-focused approaches that tend to be reactive rather than proactive often initiated in response to malaria outbreaks.

This narrow focus on treating individual cases of malaria overlooks broader social, economic, environmental risk factors including gender-based inequalities.

As Member States work towards ambitious goals set during the 2015 World Health Assembly of reducing the global malaria burden by 90% by 2030, efforts need to prioritise the underlying factors that drive transmission through a multifaceted approach, particularly recognising the social determinants like gender inequalities.

The concept of people-centred health care is based on fundamental principles that prioritize human rights, dignity, participation, equity, and partnerships.

This approach aims to create a health care system where individuals, families, and communities receive humane and holistic care, while also having the opportunity to actively engage with the health care system.

As we work towards leaving no one behind and achieving the last mile, developing and adopting more people-centred approaches, that address gender and intersectionality concerns through an analysis of power dynamics, will be critical to make significant strides towards eradicating malaria for good.

This can involve engaging with communities and stakeholders to identify their needs and develop evidence-based malaria control strategies that promote equity and inclusion.

Additionally, promoting participation of marginalized groups in decision-making and ensuring malaria interventions respect human rights and promote social justice.

Not only will this help advance Sustainable Development Goals towards gender equality but importantly will also contribute to decolonising global health and empowering communities that remain most impacted by the disease.

Unpacking the Gendered Dimensions

A people-centred approach to malaria prevention aims to prioritize the well-being of individuals and communities by establishing reliable health systems. However, power dynamics must be taken into account to prevent the perpetuation of power imbalances, hierarchies, and inequalities.

This means engaging with communities and other stakeholders to identify their needs and priorities and working together to develop evidence-based malaria control strategies.

The Community Directed Intervention (CDI) approach exemplifies the importance of extensive community engagement to identify local needs and priorities for malaria control. This includes community meetings, involving leaders and women groups, and conducting surveys on malaria burden and risk factors.

Developing evidence-based strategies through community engagement results in increased community ownership and participation, leading to higher uptake of interventions and reducing malaria transmission.

Addressing the power dynamics associated with malaria prevention requires acknowledging and tackling gendered dimensions linked with malaria prevention.

Women in some communities may lack access to education, employment, and decision-making power, which can limit their ability to protect themselves from malaria.

Additionally, cultural beliefs and practices may contribute to the unequal distribution of resources for malaria prevention and control, with men accessing more resources than women.

This underscores the importance of addressing gender roles in malaria control initiatives and empowering women to take an active role in protecting themselves and their families.

Intersectionality also has important implications for malaria control as gender intersects with other social categories to create specific vulnerabilities and challenges. For instance, women from lowest income groups are least likely to get access to healthcare.

To address these challenges, it is important for more malaria control programs to conduct systematic social and gender analysis, hearing from those affected, to better understand the subtle nuances of gendered and intersectional dimensions of power both within households and communities.

This approach can then help to identify the specific barriers and opportunities for women’s participation in malaria control initiatives. By unpacking the gendered dimensions in communities, public health officials can design targeted interventions that promote women’s empowerment, address gender inequalities, and increase women’s involvement in malaria control programs.

Confronting not Reinforcing Power Dynamics

A people-centred approach to malaria control can empower individuals by providing education and training on malaria prevention and control. It can emphasize inclusivity and centre the experiences and knowledge of those who have been historically excluded or marginalized due to factors such as racism, sexism, classism, and other systems of power.

To avoid reinforcing power dynamics in malaria control, it is crucial to involve and empower marginalized groups in decision-making. This involves consulting communities to identify their needs and priorities, promoting participation of women and marginalized groups, and designing interventions that promote equity and inclusion.

The foundation for improving community dialogue and community-led actions towards malaria elimination has been established over the years.

A case in point is the successful elimination of malaria in Cambodia’s last mile, which relied on communities in high-risk areas agreeing to increased testing, regular fever screening, and in some cases, taking preventive antimalarial medication.

A people-centred approach recognizes the significance of communities in designing and implementing malaria control programs, considering their unique social, cultural, and environmental contexts that can impact malaria transmission and control.

One illustration is the use of local languages and cultural practices to build trust and improve communication on malaria prevention and control measures through empowerment of community health workers who understand and can tailor interventions to their specific contexts.

On the other hand, a people-centred approach, which does not consider power dynamics, can unintentionally reinforce social hierarchies and exclude vulnerable populations from accessing preventative and curative treatment for malaria.

For instance, a malaria control program that only involves male community leaders and village chiefs in decision-making when distributing bed nets reinforces patriarchal power and favour wealthier households, while excluding marginalized groups such as women and those from lower socio-economic backgrounds.

In conclusion, achieving malaria elimination through people-centred approaches requires a holistic approach that actively considers issues of gender, intersectionality, and balance of power. It is crucial to ensure that these approaches do not perpetuate existing inequalities, but instead centre the experiences and knowledge of marginalized groups.

By acknowledging and addressing the ways in which different forms of oppression intersect and compound to create experiences of marginalization and exclusion, we can make meaningful strides towards malaria elimination.

To achieve this, sustaining a commitment to inclusivity, equity, and social justice is imperative in all efforts aimed at eradicating malaria and improving the health and well-being of communities affected by this disease.

This includes actively involving marginalized groups in decision-making processes, addressing social determinants of health, tailoring interventions to specific cultural and contextual factors, and promoting gender equality and women’s empowerment.

By taking a proactive and inclusive approach, we can ensure that malaria control efforts are effective, equitable, and sustainable, leading to more just and healthier communities.

Arthur Ng’etich Kipkemoi Saitabau is Post-Doctoral Fellow of the United Nations University – International Institute for Global Health.

IPS UN Bureau

 


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The War in Ukraine Triggers a Record Increase in World Military Spending

Credit: Shutterstock

By Thalif Deen
UNITED NATIONS, Apr 24 2023 – The United Nations has warned that the February 2022 Rusian invasion of Ukraine has threatened to force up to 1.7 billion people — over one-fifth of humanity — into poverty, destitution and hunger.

Long before the war, Ukraine and Russia provided about 30 per cent of the world’s wheat and barley, one-fifth of its maize, and over half of its sunflower oil. But the ongoing 14th-month-old war has undermined– and cut-off– most of these supplies.

Together, the UN pointed out, their grain was an essential food source for some of the poorest and most vulnerable people, providing more than one-third of the wheat imported by 45 African and least-developed countries (LDCs), described as “the poorest of the world’s poor”.

At the same time, Russia was the world’s top natural gas exporter, and second-largest oil exporter.

The negative fall-out from the war, and the rise in arms spending, are a blessing in disguise for US and Western arms suppliers. The US administration alone has provided an estimated 113 billion dollars in weapons, economic and humanitarian aid and security assistance to Ukraine—and with no end in sight.

As a result of the war, world military expenditures reached a new record high, according to a report from the Stockholm International Peace Research Institute (SIPRI).

The study, released April 24, says total global military expenditure grew for the eighth consecutive year in 2022. And an increase of 3.7 per cent in real terms last year resulted in a new high of $2.24 trillion.

By far the sharpest rise in spending (+13 per cent) was seen in Europe and was largely accounted for by Russian and Ukrainian spending. However, military aid to Ukraine and concerns about a heightened threat from Russia strongly influenced many other states’ spending decisions, as did tensions in East Asia.

Military expenditure in Europe, a new battleground since World War II, is the steepest year-on-year increase in at least 30 years.

The three largest spenders in 2022—the United States, China and Russia—accounted for 56 per cent of the world total.

All three, along with Britain and France, are veto-wielding permanent members of the UN Security Council who are expected to abide by one of the core principles in the UN charter: maintaining international peace and security.

The United States remains by far the world’s biggest military spender. US military spending reached $877 billion in 2022, which was 39 per cent of total global military spending and three times more than the amount spent by China, the world’s second largest spender.

The 0.7 per cent real-term increase in US spending in 2022 would have been even greater had it not been for the highest levels of inflation since 1981, according to the SIPRI study.

Dr Nan Tian, Senior Researcher with SIPRI’s Military Expenditure and Arms Production Programme, said “the continuous rise in global military expenditure in recent years is a sign that we are living in an increasingly insecure world.’

She said States are bolstering military strength in response to a deteriorating security environment, which they do not foresee improving in the near future.

Ukraine’s military spending reached $44.0 billion in 2022. At 640 per cent, this was the highest single-year increase in a country’s military expenditure ever recorded in SIPRI data.

As a result of the increase and the war-related damage to Ukraine’s economy, the military burden (military spending as a share of GDP) shot up to 34 per cent of GDP in 2022, from 3.2 per cent in 2021, according to the SIPRI study.

“The invasion of Ukraine had an immediate impact on military spending decisions in Central and Western Europe. This included multi-year plans to boost spending from several governments,” said Dr Diego Lopes da Silva, Senior Researcher with SIPRI’s Military Expenditure and Arms Production Programme.

“As a result, we can reasonably expect military expenditure in Central and Western Europe to keep rising in the years ahead,” he said.

Some of the sharpest increases were seen in Finland (+36 per cent), Lithuania (+27 per cent), Sweden (+12 per cent) and Poland (+11 per cent).

‘While the full-scale invasion of Ukraine in February 2022 certainly affected military spending decisions in 2022, concerns about Russian aggression have been building for much longer,’ said Lorenzo Scarazzato, Researcher with SIPRI’s Military Expenditure and Arms Production Programme.

‘Many former Eastern bloc states have more than doubled their military spending since 2014, the year when Russia annexed Crimea,’ while Russia and Ukraine have raised military spending as war rages on.

Russian military spending grew by an estimated 9.2 per cent in 2022, to around $86.4 billion. This was equivalent to 4.1 per cent of Russia’s gross domestic product (GDP) in 2022, up from 3.7 per cent of GDP in 2021.

Figures released by Russia in late 2022 show that spending on national defence, the largest component of Russian military expenditure, was already 34 per cent higher, in nominal terms, than in budgetary plans drawn up in 2021.

‘The difference between Russia’s budgetary plans and its actual military spending in 2022 suggests the invasion of Ukraine has cost Russia far more than it anticipated,’ said Lucie Béraud-Sudreau, Director of SIPRI’s Military Expenditure and Arms Production Programme.

Ukraine’s military spending reached $44.0 billion in 2022. At 640 per cent, this was the highest single-year increase in a country’s military expenditure ever recorded in SIPRI data.

As a result of the increase and the war-related damage to Ukraine’s economy, the military burden (military spending as a share of GDP) shot up to 34 per cent of GDP in 2022, from 3.2 per cent in 2021.

Other notable developments, according to SIPRI included:

** The real-terms increase in world military spending in 2022 was slowed by the effects of inflation, which in many countries soared to levels not seen for decades. In nominal terms (i.e. in current prices without adjusting for inflation), the global total increased by 6.5 per cent.

** India’s military spending of $81.4 billion was the fourth highest in the world. It was 6.0 per cent more than in 2021.

** In 2022, military spending by Saudi Arabia, the fifth biggest military spender, rose by 16 per cent to reach an estimated $75.0 billion, its first increase since 2018.

** Nigeria’s military spending fell by 38 per cent to $3.1 billion, after a 56 per cent increase in spending in 2021.

** Military spending by NATO members totalled $1232 billion in 2022, which was 0.9 per cent higher than in 2021.

** The United Kingdom had the highest military spending in Central and Western Europe at $68.5 billion, of which an estimated $2.5 billion (3.6 per cent) was financial military aid to Ukraine.

** In 2022, Türkiye’s military spending fell for the third year in a row, reaching $10.6 billion—a decrease of 26 per cent from 2021.

** Ethiopia’s military spending rose by 88 per cent in 2022, to reach $1.0 billion. The increase coincided with a renewed government offensive against the Tigray People’s Liberation Front in the north of the country.

IPS UN Bureau Report

 


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Education Cannot Wait Grant Gives Refugees, Displaced Children Hope

By External Source
Apr 24 2023 (IPS-Partners)

 

 
Colombia’s government is expanding its educational response to the Venezuelan regional crisis, and its efforts are supported by Education Cannot Wait (ECW), which announced USD 12 million grant. However, the need is great, and ECW estimates financial support of USD 46.4 million is needed for the multi-year resilience response.